Injectable skin treatments have revolutionized the aesthetic medicine landscape, offering effective solutions for various skin concerns without the need for invasive procedures.
Among the most popular options are Rejuran, Skin Boosters, and Profhilo—three distinct treatments that promise youthful, radiant skin through different mechanisms of action.
Understanding the differences between these treatments is crucial for making informed decisions about your skincare journey.
Each treatment targets specific skin concerns and works through unique pathways to achieve optimal results.
Understanding Rejuran: The Skin Healing Revolution
Rejuran represents a breakthrough in regenerative aesthetics, utilizing the power of polynucleotides derived from salmon DNA to restore and rejuvenate damaged skin.
This innovative treatment has gained significant popularity due to its remarkable ability to address fundamental skin health issues at the cellular level.
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What Makes Rejuran Unique
The core ingredient in Rejuran is PDRN (polydeoxyribonucleotide), which is extracted through a specialized process from salmon milt.
These polynucleotides are remarkably similar to human DNA fragments, making them highly biocompatible and safe for injection into human skin.
When introduced into the dermis, PDRN activates the skin’s natural regenerative processes by stimulating fibroblast proliferation and enhancing collagen synthesis.
This cellular-level activation leads to comprehensive skin improvement from within, addressing not just surface concerns but fundamental skin health.
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Primary Benefits of Rejuran Treatment
The regenerative properties of Rejuran offer multiple advantages for skin health and appearance:
Cellular Repair and Regeneration: Rejuran works at the molecular level to repair damaged skin cells, promoting faster healing and cellular turnover. This process helps address various forms of skin damage, including UV damage, environmental stress, and natural aging.
Scar Reduction and Texture Improvement: The collagen-stimulating properties of PDRN make Rejuran particularly effective for treating acne scars, surgical scars, and other textural irregularities. The treatment promotes the formation of new, healthy tissue that gradually replaces damaged areas.
Pore Size Reduction: By improving skin density and promoting collagen formation, Rejuran can significantly reduce the appearance of enlarged pores, creating a smoother, more refined skin texture.
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Enhanced Skin Elasticity: The treatment stimulates the production of elastin fibers, which are essential for maintaining skin flexibility and resilience. This leads to firmer, more youthful-looking skin.
Skin Balance Restoration: Rejuran helps regulate sebum production and restore the skin’s natural pH balance, making it particularly beneficial for individuals with oily or problematic skin conditions.
Exploring Skin Boosters: Hydration at Its Finest
Skin boosters represent a category of treatments specifically designed to deliver intense hydration and subtle enhancement to the skin. These treatments utilize hyaluronic acid, a naturally occurring substance in the human body, to achieve remarkable improvements in skin quality and appearance.
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The Science Behind Skin Boosters
When injected into the skin as part of a skin booster treatment, these molecules attract and bind water from the surrounding tissues, creating a reservoir of hydration within the dermis.
Unlike traditional dermal fillers that add volume to specific areas, skin boosters work by improving overall skin quality through enhanced hydration and subtle stimulation of natural processes.
The treatment creates a more youthful appearance through improved skin texture, increased luminosity, and enhanced elasticity.
Key Advantages of Skin Booster Treatments
Deep Hydration: Skin boosters provide hydration that penetrates beyond the surface layers, creating lasting moisture retention within the skin.
This deep hydration helps plump the skin from within, reducing the appearance of fine lines and creating a more youthful complexion.
Natural Glow Enhancement: The improved hydration and skin quality achieved through skin boosters creates a natural, healthy glow that appears radiant and fresh.
This effect is often described as the “glass skin” look that many patients desire.
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Improved Skin Texture: Regular skin booster treatments can significantly improve skin smoothness and softness, addressing rough or uneven texture issues that develop over time.
Elasticity Improvement: While primarily focused on hydration, skin boosters also provide mild stimulation of collagen and elastin production, contributing to improved skin firmness and elasticity.
Versatile Application: Skin boosters can be used on various areas of the body, including the face, neck, hands, and décolletage, making them versatile tools for comprehensive skin rejuvenation.
Profhilo: Revolutionary Bio-Remodeling Technology
Profhilo represents the latest advancement in injectable aesthetic treatments, introducing the concept of bio-remodeling to the world of non-surgical skin rejuvenation.
This innovative treatment combines the hydrating benefits of hyaluronic acid with unique spreading technology to achieve comprehensive skin improvement.
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The Profhilo Difference
What sets Profhilo apart from other treatments is its unique formulation and application technique.
The treatment contains an exceptionally high concentration of hyaluronic acid—64mg per 2ml syringe—combining both high and low molecular weight hyaluronic acid in equal proportions.
This specific combination allows Profhilo to spread extensively beneath the skin after injection, creating a bio-remodeling effect that stimulates natural collagen and elastin production while providing intense hydration.
The treatment doesn’t add volume like traditional fillers but instead improves the quality and structure of existing skin.
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Profhilo’s Comprehensive Benefits
Bio-Remodeling Action: Profhilo’s unique ability to spread beneath the skin creates a three-dimensional network that stimulates natural tissue regeneration and remodeling.
This process leads to improved skin architecture and enhanced structural integrity.
Multi-Level Skin Improvement: The treatment works on multiple layers of the skin simultaneously, addressing surface hydration, dermal thickness, and deep tissue quality. This comprehensive approach creates more natural and long-lasting results.
Minimal Injection Points: Profhilo utilizes the Bio Aesthetic Points (BAP) technique, requiring only five injection points per side of the face.
This minimally invasive approach reduces discomfort and downtime while achieving excellent coverage.
Natural-Looking Results: Because Profhilo enhances existing tissue rather than adding volume, the results appear completely natural, with improved skin quality that develops gradually over time.
Long-Lasting Effects: The bio-remodeling effects of Profhilo can last up to six months, providing sustained improvement in skin quality and appearance.
Detailed Treatment Comparison
| Feature | Rejuran | Skin Boosters | Profhilo |
|---|---|---|---|
| Primary Ingredient | Polynucleotides (PDRN) from salmon DNA | Hyaluronic acid with vitamins/minerals | High-concentration hyaluronic acid (64mg) |
| Main Mechanism | Cellular repair and regeneration | Deep hydration and subtle enhancement | Bio-remodeling and tissue stimulation |
| Treatment Sessions | 3-4 sessions, 3-4 weeks apart | 3 sessions, 2-4 weeks apart | 2 sessions, 4 weeks apart |
| Primary Benefits | Scar reduction, pore minimization, texture improvement | Intense hydration, natural glow, elasticity | Bio-remodeling, firmness, comprehensive rejuvenation |
| Ideal Candidates | Damaged skin, scarring, texture issues | Dehydrated skin, dullness, fine lines | Skin laxity, aging signs, volume loss |
| Results Timeline | 3-4 weeks after final session | Immediate with progressive improvement | 4-6 weeks for full effects |
| Duration of Results | 6-12 months | 4-6 months | 6-9 months |
| Pain Level | Mild to moderate | Minimal | Minimal |
| Downtime | 1-2 days mild swelling | Minimal to none | Minimal to none |
Treatment Protocols and Expectations
Rejuran Treatment Journey
The typical Rejuran protocol involves three to four treatment sessions spaced approximately one month apart.
During each session, multiple small injections are administered across the treatment area using fine needles. The treatment takes approximately 30-45 minutes to complete.
Patients may experience mild swelling, redness, and tenderness for 24-48 hours following treatment.
These effects are normal and indicate the activation of the skin’s healing response. Results typically become apparent after the second or third session, with continued improvement over the following months.
Skin Booster Protocol
Skin booster treatments typically require three sessions spaced 2-4 weeks apart for optimal results. The treatment involves multiple micro-injections across the face, neck, or other treatment areas. Each session takes approximately 20-30 minutes.
Side effects are generally minimal, with possible mild redness or slight swelling at injection sites that resolves within a few hours.
Patients often notice improved skin hydration and glow within days of the first treatment, with cumulative benefits developing over the treatment series.
Profhilo Treatment Schedule
Profhilo follows a unique two-session protocol with treatments spaced exactly four weeks apart.
The Bio Aesthetic Points (BAP) technique involves just ten injection points total (five per side of the face), making it one of the least invasive injectable treatments available.
Mild swelling or tenderness at injection sites may occur but typically resolves within 24 hours.
The bio-remodeling effects develop gradually, with most patients noticing significant improvement in skin quality 4-6 weeks after the second treatment.
Cost Considerations and Value Analysis
The investment in injectable skin treatments varies significantly based on geographic location, practitioner expertise, and specific treatment requirements.
Understanding the cost-to-benefit ratio helps in making informed decisions about which treatment offers the best value for individual needs.
Rejuran Investment
Rejuran treatments typically range from $400-$800 per session, with most patients requiring 3-4 sessions for optimal results.
While the initial investment may seem substantial, the long-lasting nature of results (6-12 months) and the comprehensive skin improvement achieved often provide excellent value for patients with significant skin concerns.
Skin Booster Costs
Skin booster treatments generally cost between $300-$600 per session, with three sessions required for the initial treatment series.
The relatively lower per-session cost makes skin boosters accessible for patients seeking gradual skin improvement with a more modest budget.
Profhilo Pricing
Profhilo treatments typically range from $500-$800 per session, with only two sessions required for the complete treatment protocol.
Despite the higher per-session cost, the total treatment investment is often comparable to other options while providing unique bio-remodeling benefits.
Combining Treatments for Enhanced Results
Many aesthetic practitioners recommend combining different injectable treatments to achieve comprehensive skin rejuvenation. The synergistic effects of multiple treatments can address various skin concerns simultaneously while maximizing overall results.
Strategic Treatment Combinations
Rejuran and Profhilo Combination: This powerful combination addresses both cellular repair and bio-remodeling, providing comprehensive skin regeneration.
Typically, treatments are staggered with Profhilo performed first to prepare the skin, followed by Rejuran to promote healing and regeneration.
Skin Boosters with Other Treatments: Skin boosters can be effectively combined with either Rejuran or Profhilo to enhance hydration and maintain results between primary treatment cycles.
Treatment Sequencing Considerations
When combining treatments, proper sequencing and timing are crucial for optimal results and safety. Most practitioners recommend spacing different treatments at least 2-4 weeks apart to allow proper healing and to avoid overwhelming the skin’s natural processes.
Safety Profile and Side Effects
All three treatments have established safety profiles when performed by qualified practitioners using genuine products. Understanding potential side effects helps patients make informed decisions and prepare for the treatment experience.
Common Side Effects Across All Treatments
- Mild swelling at injection sites (24-48 hours)
- Temporary redness (few hours to one day)
- Minor bruising (possible, varies by individual)
- Slight tenderness or sensitivity (1-3 days)
Treatment-Specific Considerations
Rejuran Safety: The use of salmon-derived polynucleotides requires screening for fish allergies, though allergic reactions are extremely rare due to the purification process.
Skin Booster Safety: Hyaluronic acid is naturally occurring in the human body, making allergic reactions virtually impossible. However, reactions to additives or preservatives in some formulations can occur.
Profhilo Safety: The high concentration of hyaluronic acid in Profhilo is well-tolerated, with side effects typically limited to normal injection-related responses.
Choosing the Right Treatment for Your Needs
Selecting the most appropriate treatment depends on individual skin concerns, goals, budget, and lifestyle factors. Understanding how each treatment addresses specific issues helps guide the decision-making process.
When to Choose Rejuran
Rejuran is ideal for patients with:
- Acne scarring or other textural irregularities
- Enlarged pores requiring reduction
- Sun-damaged or environmentally stressed skin
- Oily or problematic skin requiring balance restoration
- Desire for comprehensive cellular-level skin repair
When to Choose Skin Boosters
Skin boosters are perfect for patients seeking:
- Intense hydration for dry or dehydrated skin
- Natural glow and luminosity enhancement
- Subtle skin quality improvement
- Maintenance between other treatments
- Budget-conscious approach to skin rejuvenation
When to Choose Profhilo
Profhilo is optimal for patients wanting:
- Comprehensive bio-remodeling effects
- Treatment of skin laxity and firmness loss
- Minimal injection points and downtime
- Natural-looking anti-aging results
- Premium treatment with long-lasting effects
Frequently Asked Questions
How do these treatments compare to traditional dermal fillers?
Unlike traditional dermal fillers that add volume to specific areas, Rejuran, Skin Boosters, and Profhilo focus on improving overall skin quality. They work by enhancing the skin’s natural structure, hydration, and regenerative processes rather than simply filling lines or adding volume to particular features.
Can these treatments be performed together in the same session?
Generally, these treatments should not be performed simultaneously in the same session. Most practitioners recommend spacing different treatments 2-4 weeks apart to allow proper healing and to avoid overwhelming the skin. However, they can be part of a comprehensive treatment plan when properly sequenced.
How long do the results from each treatment typically last?
Results duration varies by treatment: Rejuran effects typically last 6-12 months, Skin Boosters provide benefits for 4-6 months, and Profhilo results can last 6-9 months. Individual factors such as age, skin condition, lifestyle, and skincare routine can influence how long results are maintained.
Are there any age restrictions for these treatments?
These treatments are generally suitable for adults over 18 years old. However, the ideal candidate age varies by treatment type and individual skin concerns. Most patients begin considering these treatments in their late twenties to early thirties for preventive care, while others seek them later to address established aging signs.
What should I expect during the recovery period?
Recovery is generally minimal for all three treatments. Common experiences include mild swelling, redness, and slight tenderness at injection sites lasting 24-48 hours.
Most patients can return to normal activities immediately, though strenuous exercise and excessive sun exposure should be avoided for 24-48 hours post-treatment.
How do I choose between these treatments if I have multiple skin concerns?
The best approach is consultation with a qualified aesthetic practitioner who can assess your specific skin concerns, goals, and medical history.
They can recommend the most appropriate single treatment or combination of treatments to address your needs effectively while considering your budget and lifestyle factors.
Are the results from these treatments permanent?
None of these treatments provide permanent results, as they work with the skin’s natural processes that continue to change over time.
However, they can provide long-lasting improvement in skin quality, and maintenance treatments can help sustain results indefinitely.
Can these treatments be combined with other aesthetic procedures?
Yes, these treatments can often be integrated into comprehensive aesthetic treatment plans that may include other procedures such as laser treatments, chemical peels, or energy-based devices. Proper timing and sequencing are essential to ensure safety and optimal results.
What factors affect the cost of these treatments?
Treatment costs vary based on geographic location, practitioner expertise and qualifications, clinic reputation, product authenticity, number of sessions required, and the extent of the treatment area.
It’s important to prioritize qualified practitioners and genuine products over lower-cost alternatives.
How soon can I see results from each treatment?
Results timelines vary: Skin Boosters often provide immediate hydration benefits with progressive improvement over weeks, Profhilo results develop gradually over 4-6 weeks following the second treatment, and Rejuran effects typically become apparent 3-4 weeks after the final session with continued improvement over months.
Are there any contraindications for these treatments?
Common contraindications include pregnancy and breastfeeding, active skin infections or inflammation in the treatment area, bleeding disorders, autoimmune conditions, and allergies to treatment components.
A thorough medical consultation is essential to determine suitability for treatment.
How do I maintain results between treatment sessions?
Maintaining results involves consistent skincare routine with appropriate cleansing, moisturizing, and sun protection, healthy lifestyle habits including proper hydration and nutrition, avoiding excessive sun exposure and environmental damage, and following post-treatment care instructions provided by your practitioner.